Investigating the Mechanisms and Therapeutic Applications of Chalcones

Investigating the Mechanisms and Therapeutic Applications of Chalcones

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Introduction: Chalcones, are a group of organic compounds containing two aromatic rings bridged by a three-carbon -a, ?; unsaturated carbonyl system.This attracted much attention because of their versatility in pharmacological profiles.Aims & Objectives: To investigate the therapeutic efficacy of a particular chalcone derivative, namely (E)-1-(4- bromophenyl)-3-(4-chlorophenyl) prop-2-ene-1-one.

Place and Duration of Study: It was conducted in the Pharmacology Laboratory of the Institute of Basic Medical Sciences, Pre-Production Khyber Medical University, Peshawar, and the University of Malakand for about one year.Material & Method: This was a lab-based experimental study.The therapeutic efficacy of a chalcone derivative, (E)-1- (4-bromophenyl)-3-(4-chlorophenyl) prop-2-ene-1-one was assessed through an experiment on pain and inflammation in mice.

Claisen-Schmidt condensation reaction and spectroscopic SHORTS tools were used.Results: Pharmacological data proved a significant decrease in pain and inflammation as compared to Diclofenac Sodium.Reduction of 75.

20% in acetic acid-induced writhing as compared to 84.4% with Diclofenac.After 3 hours, there was 67.

08% reduction in edema.Conclusion: This study provides evidence that chalcone derivatives in moderation may be effective and safer than present-day drugs that address pain and inflammation.This result may need to be further clinically related to potentially translate them in different patient populations in terms of efficacy and safety.